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哈佛大學(xué)醫(yī)學(xué)院/南醫(yī)大二附院Hengcheng Zhang教授多篇論文陷爭議

近日，《IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation》發(fā)表于“?Journal of Inflammation Research”雜志，《IL-21-producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts》發(fā)表于“JCI Insight”雜志的兩篇研究論文引起關(guān)注。上述兩項研究均由哈佛大學(xué)醫(yī)學(xué)院/南醫(yī)大二附院Hengcheng Zhang教授擔(dān)任第一作者。

目前，第一篇論文公開討論的重點(diǎn)在于文章內(nèi)2處核心圖片的視覺呈現(xiàn)問題，第二篇論文的爭議重點(diǎn)聚焦于文章內(nèi)4處核心圖表的視覺呈現(xiàn)問題。盡管同行已在公開平臺發(fā)起問詢，但關(guān)于此類問題是否具有合理解釋的討論仍在繼續(xù)。

以下為基于公開素材的客觀數(shù)據(jù)信息復(fù)述：

論文1標(biāo)題：IL-6/IL-6R Signaling Blockade Alleviates Chronic Allograft Rejection by Modulating Germinal Center B Cells and Allograft Inflammation in Murine Cardiac Transplantation

發(fā)表期刊：?Journal of Inflammation Research?

作者信息：Renfei Xia, Xiaoyi Shi, Hengcheng Zhang, Wenli Zeng, Zhe Yang, Jian Xu, Jianning Wang, Yun Miao, Tao Liao

所屬單位：

1

Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, People's Republic of China.

2

Department of Organ Transplantation, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, 510317, People's Republic of China.

3

Department of Urology, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, 210003 People's Republic of China.

4

Department of Urology, The First Affiliated Hospital of Shandong First Medical University, Jinan, 250014, People's Republic of China.

核心素材呈現(xiàn)：

Figure 1 and Figure 6: Unexpected overlap between images that should show different experimental conditions. I've added the coloured rectangles to show where I mean.

Figure 1D:

Figure 6：

論文2標(biāo)題：IL-21-producing effector Tfh cells promote B cell alloimmunity in lymph nodes and kidney allografts

發(fā)表期刊：JCI Insight

作者信息：Hengcheng Zhang , Cecilia B Cavazzoni, Manuel A Podestà , Elsa D Bechu , Garyfallia Ralli , Pragya Chandrakar, Jeong-Mi Lee , Ismail Sayin, Stefan G Tullius, Reza Abdi, Anita S Chong, Bruce R Blazar, Peter T Sage

所屬機(jī)構(gòu)：Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA

核心素材呈現(xiàn)：

流式細(xì)胞術(shù)門控策略僅以摘要形式呈現(xiàn)，未提供單個重復(fù)圖、排除標(biāo)準(zhǔn)或樣本間一致的門控信息。這導(dǎo)致門控過程具有主觀性，且陽性群體的報告具有選擇性。此外，僅根據(jù)已發(fā)表的圖表，觀察到本文中存在多處圖像高

度相似的情況：

(1)Figure 1I和Figure 4C疑似高度重復(fù)

(2)Figure 4D和Figure 6C疑似高度重復(fù).

(3)Figure 1J和Figure 4D疑似高度重復(fù).

(4)Figure 5E內(nèi)的兩幅圖疑似高度重復(fù).

截止發(fā)稿前，相關(guān)團(tuán)隊暫無公開回應(yīng)。

https://www.pubpeer.com/publications/5E92FCD73C80CD6A1F08C5D2119615